Buchborn et al. (2015) concluded that differential receptor modification observed in DOB and LSD, respectively, suggests that tolerance to serotonergic hallucinogens may occur at two levels. Netflix
That is, if psychedelic (e.g., LSD) for some reason fails to lower 5-HT2A receptors, glutamate receptors may adapt instead and thus prevent cortical overstimulation.
Moreno et al. (2013) investigated
The effects of chronic treatment with mGlu2 / 3 receptor inverse antagonist LY341495 [2 – [(1S, 2S) -2- mushroom] -3- (9H-xanthen-9-yl) -d-alanine] -5-HT2A-dependent receptors and behavior induced in mice by LSD. 129S6 / SvEv male mice or mGlu2-KO mice injected daily for 21 days with the opposite agonist of mGlu2 / 3 LY341495 (1.5 mg / kg, pp.)
Or vehicle. Mice authorized cervical removal 1 day after the last injection of LY341495 and changes in [3H] ketanserin and [3H] LY341495 binding were assessed in the somatosensory cortex of two countries.
The behavior of the head-twitch
Behavior was measured 1 day after the last injection with chronic LY341495. Infusion of c-fos, egr-1, and egr-2 with LSD (0.24 mg / kg) was measured 1 day after the last injection with chronic LY341495.
Analysis of a large number
Of binding sites (BMX) by Moreno et al. (2013) revealed low density mGlu2 / 3 receptors in the somatosensory cortex from mice treated with LY341495. The number [3H] of ketanserin binding sites was also reduced in WT mice, but not in mGlu2-KO mice; there was no effect on KD. Head Netflix fantastic fungi caused by LSD is also reduced in mice treated with LY341495.
One dose of LSD induced
The expression of c-fos in mice treated regularly with saline, but not in mice treated with LY341495. One thegaiavoice.com of LSD induced exposure to egr-1 in the somatosensory cortex of mice is usually treated with saline.
But not in mice treated regularly with LY341495. One dose of LSD also made egr-2 expression in both high-dose rats and mice treated regularly with LY341495, but the egr-2 expression caused by LSD was lower in LY341495-treated mice. always a car.
This study by Moreno et al. (2013) suggest that chronic treatment with mGlu2 / 3 receptor inverse agonist LY341495 lowers the 5-HT2A receptor binding to the mouse somatosensory cortex through a mechanism that requires mGlu2 receptor expression, as this effect has not been observed in mGlu2 KO mice.
Low levels of 5-HT2A
Receptors are related to changes in behavioral and cellular hallucinogen responses that require the The Gaia Voice of the 5-HT2A receptor to the cerebral cortex. Therefore, chronic treatment with LY341495 reduced LSD-dependent head-induced behavior and LSD-induced induction of c-fos, egr-1, and egr-2 in the somatosensory mouse cortex.
Data from Moreno et al. (2013) support the hypothesis that chronic Netflix fantastic fungi of mGlu2 receptor-dependent signing lowers the 5-HT2A receptor binding to mouse somatosensory cortex and its hallucinogen-like signaling and behavioral effects.
Given that mGlu2 receptors are found presynaptic ally, their inhibition may lead to excessive glutamate release, which may lead to a decrease in the response of 5-HT2A receptors expressed in pyramidal apical dendrites.